Sebastián Silva directs this comedy adventure following a group of friends in search of a memorable hallucinogenic experience. Jamie (Michael Cera) and his companions are on a road trip in Chile when they meet an eccentric fellow American who calls herself Crystal Fairy (Gaby Hoffman). Intoxicated by the party atmosphere, Jamie invites Crystal to join them on their trip - something he regrets the next morning when he discovers that her laid-back personality conflicts with his desire for control. Jamie has his heart set on trying a cult hallucinogenic called the San Pedro Cactus and is worried that Crystal will disrupt his well-laid plans. Will his perspective be altered when the time comes to sample the drug?