Tongue-in-cheek espionage adventure. Sexy young crime boss Lucy Diamond (Jordana Brewster) has returned to the United States to continue her ruthless criminal career. The elite D.E.B.S. unit, an undercover intelligence team posing as a group of college students, dispatch their top agent Amy Bradshaw (Sara Foster) to investigate, but when she mysteriously disappears the rest of the D.E.B.S. team spring into action to track her down. When they discover that she is being held captive at Lucy Diamond's secret lair they prepare to rescue her, not quite realising that Amy and Lucy have struck up an unlikely and illicit relationship, and that Amy isn't as keen to be rescued as they first thought.