Comedy in which two teenagers with nothing in common are brought together in a very unexpected way. Woody (Kevin Zegers) and Nell (Samaire Armstrong) have been next door neighbours since childhood, but couldn't be any different. He's a jock, she's a nerd, she's graduating to Yale, he's going to a second rate college on a football scholarship. Nell and Woody are not at all friendly and normally have nothing to say to one another, but one day during a class field trip to a historical museum, the two fall under the spell of an Incan icon and when they awake the next morning, Woody's mind is in Nell's body, and vice versa. Neither is comfortable with their sudden gender switch or having to assume the other's personalities, but they quickly realise that until they can find a way to reverse the spell, they have to work together.