Drama based on a true story. The movie centres around a HIV-positive Brooklyn woman named Ana (Queen Latifah), who channels her energy and regret over past drug addiction into working for 'Life Support', an AIDS outreach group. Ana, who contracted the virus by sharing drugs with her husband Slick (Wendell Pierce), displays an admirable though obsessive passion for her job that puts her health at risk, and her stubbornness threatens to drive her already fractured family away. Ana's teenage daughter Kelly (Rachel Nicks) is particularly at odds with Ana; she lives with her grandmother Lucille (Anna Deavere Smith), and isn't interested in moving back in with Ana when Lucille announces she's moving to Virginia. When Kelly's HIV-infected gay friend Amare (Evan Ross) disappears, Ana, looking to connect with her daughter while helping a lost soul, throws herself into searching for him. She embarks on a dangerous but necessary journey, and as she seeks to save one life and heal another, Ana learns a poignant lesson about loving and letting go.