This black-comedy stars Jason Schwartzman as Ross - a young man, recently split from his girlfriend, and addicted to crystal meth. Over the course of a long weekend Ross battles to get his next fix and fixates over his breakup. His regular drug supplier, Spider Mike, has forgotten where he's put his stash and while he's searching Ross is asked by Spider Mike's girlfriend, Cookie [Mena Suvari] to pick up a friend of hers called Nikki [Brittany Murphy]. Reluctantly he agrees and discovers she may have some drugs for him, from The Cook [Mickey Rourke]. All the time the police are after Spider Mike and in his drug-induced state he decides to track down who has set him up.