Advertising executive Ed Waxman (Brendan Fehr) is overworked and undersexed. He must come up with a great new ad campaign within 48 hours or he'll be fired. But his babe magnet brother, Cooper (Chris Klein), has other ideas: to get his stressed-out brother laid. From meeting single mothers to strippers to desperate older ladies, each dating encounter is a disaster. Ed has resigned himself to the fact that he's about to lose his job and will never have sex again, until he meets the woman of his dreams. Now, with hope and luck on his side, maybe he'll be able to save his job and have sex, all in the course of 'The Long Weekend'.