When danger looms in Townsville, the call goes out for Bubbles, Blossom, and Buttercup - The Powerpuff Girls. Under the watchful eye of their mentor Professor Utonium, the girls fly into action against a colourful gallery of nefarious villains, saving the day before bedtime. A chance meeting gives Mojo Jojo, Him, Fuzzy Lumpkins and Princess the idea to team up to defeat The Powerpuff Girls. Together, they create the world's first criminal supergroup, the Beat-Alls, unleashing an eight-days-a-week wave of crime and mayhem in Townsville. The combined power of the Bad Four creates hard days and nights for Blossom, Bubbles and Buttercup, who find defeating the Beat Alls to be a long and winding road. Only by enlisting the help of Moko Jojo, a mysterious 'performance criminal', are the Powerpuff Girls able to curtail the brutish invasion.