Comedy following George Washington Winsterhammerman (Zach Galifianakis), a supervisor at the Jeffers Corporation. George's marriage is falling apart and his brother, after being released from prison, decides to set up a freedom-of-expression movement in George's garden. At work, George is tempted by Charisma (Mia Maestro), a woman who works on the floor above him. To make matters worse, people everywhere are actually exploding from stress and George realises he may have symptoms of the illness. Jeffers (D.W. Moffett) believes mind control is the answer to the epidemic.