Long time no Z. When a mystery assassin starts killing the world's most beautiful people, haute-shot Interpol agent Valentina Valencia (Penélope Cruz) learns the key to this deadly plot lies with former models Derek (Ben Stiller) and Hansel (Owen Wilson). Recruited for a top secret mission, they must return to the world of high fashion, reclaim their fame, and save the day. The only things standing in their way: the criminal mastermind Mugatu (Will Ferrell) and his evil fashion protégé (Kristen Wiig). Prepare for a dangerously sexy adventure where looks really can kill.