Garfield, the cartoon cat, returns in a feature-length CGI animated movie. Tired with his routine as a comic strip star in Cartoon World, Garfield escapes the page, with his dim-witted canine companion Odie, to live in the Real World with no prospect of return. His initial excitement quickly evaporates when he realises he'll be spending his nights in a leaky old building and living off dumpster scraps. Furthermore, the neighbourhood cats don't believe he's the real Garfield from the newspaper comic strip. When the local paper decides to replace the Garfield comic strip for good, he realises the enormity of his mistake and begs his old funny paper co-workers in Cartoon World to somehow find a way to bring him and Odie back before their strip is permanently cancelled.