John Mason (James Stewart) is a young New York lawyer newly married to the beautiful Jane (Carole Lombard). Their dreams of a wonderful life together fail to materialise in the real world as they endure one great disappointment after another, beginning with John being called to the office urgently on the eve of their honeymoon! The birth of their son provides a much-needed bright spot, but their marriage is still a far from stable one. One night, driven to despair, they decide to separate, but on returning home discover that their baby is ill with pneumonia... and the only serum that can save him is hundreds of miles away. Introduced by Tony Curtis'