David Lynch's acclaimed tale of murder and amnesia in Los Angeles. Having narrowly survived a murder attempt and a car crash, a shocked and wounded woman (Laura Elena Harring) takes refuge in a nearby apartment. When she is discovered the next morning by the apartment's official resident, aspiring actress Betty Elms (Naomi Watts), she confesses that she neither knows who she is nor what happened to her. The two women then begin to investigate, and it gradually becomes clear that they have known each other in the past. Meanwhile, a young film director (Justin Theroux) finds that the mob are taking an unusual interest in the casting of his latest film.