Shortly after co-pilot Nick Vanzant (James Spader) joins 22nd medical rescue vessel the Nightingale 299, the ship receives a distress call from a mine on a rogue moon. The signal was apparently sent by Karl Larson, abusive former lover of the Nightingale's chief medical officer, Kaela Evers (Angela Bassett). The crew have to make a dimension jump to get to the moon, during which the captain is killed and the fuel supply is damaged. Nick takes command, and upon arrival the ship docks with a patrol vehicle carrying the sole survivor of the mining expedition; Karl's son, Troy, who is carrying a strange alien artefact. However, when Nick travels to the moon in search of fuel, Kaela soon realizes that Troy Larson is not all he seems.