In the first series the team release three women from a mysterious crypt in Scotland, however their disappearance does not go unnoticed by the Cabal, who are determined to reclaim what is theirs. An investigation into a string of bizarre robberies leads Magnus and Will to a gang of thieves, the team attempt to capture a rare and deadly creature under the watchful eye of a news crew, and they must complete a series of cryptic tests in a secret labyrinth that can only be achieved using their unique powers.
As the sci-fi show returns for a second series Magnus obtains top-secret files about a catastrophic plan for the Sanctuary Network that involves her daughter Ashley. Magnus challenges the Cabal and must decide between saving her daughter or risking the survival of the entire Sanctuary Network. After receiving information from the head of the Tokyo Sanctuary, Magnus, Will and skilled fighter Kate (Agam Darshi) embark on a global investigation. They travel to India to examine the connection between a murder and the Cult of Kali, an ancient cult whose followers can foretell disaster. When Will falls ill and disappears, Magnus knows they are dealing with something extremely powerful.
The third series opens with the team desperately trying to find a way to prevent catastrophic and global disasters. A routine mission to retrieve an Abnormal is complicated by the team's need to stage a bank heist, Kate gains superhero-like abilities when an Abnormal attaches itself to her, and the team embark on a mission to find the gateway to a hidden city and Magnus' father.